Delayed gastric emptying is related to cardiovascular autonomic neuropathy in Chinese patients with type 2 diabetes
| Journal | Volume 74 - 2011 |
| Issue | Fasc.1 - Original articles |
| Author(s) | R.W. Bian, Q.L. Lou, L.B. Gu, A.P. Kong, W.Y. So, G.T. Ko, X.J. Ouyang, Y.Z. Mo, R.C. Ma, J.C. Chan, C.C. Chow |
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| (1) Diabetes Care and Research Center, Jiangsu Province Institute of Geriatrics, Nanjing, China; and Department of Endocrinology and Metabolism, Jiangsu Province Institute of Geriatrics, Nanjing, China ; (2) Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China ; (3) Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China. |
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Background and study aims : Delayed gastric emptying (DGE) is the commonest gastrointestinal (GI) complication in type 2 diabetes. We aimed to evaluate the association between DGE and cardiovascular autonomic neuropathy (CAN) in type 2 diabetes. Patients and methods : A total of 71 Chinese patients (39 men and 32women, aged 60-90 years) and 30 controls (12 men and 18 women, aged 50-79 years) were studied in Nanjing, China. The gastric emptying was assessed by 13C-octanoic acid breath test (OBT) and gastric emptying ultrasonography (GEU). Cardiovascular autonomic neuropathy (CAN) was assessed by a scoring system being validated before. Results : The diabetic patients, except for a higher plasma glu- cose level, had similar characteristics compared to the non-diabet- ic controls. Diabetic patients had higher incidence of DGE and CAN than controls (48.5% vs. 10.7%, p = 0.001). Among diabetic patients with DGE (n = 27), 18 (66.7%) had CAN and 9 (33.3%) did not. Corresponding figures for those without DGE (n = 39) were 14 (35.9%) and 25 (64.1%), respectively (p = 0.014). Diabetes was independently associated with the risk of DGE with odd ratio (95% CI) of 15.6 (1.92, 127.06) (p = 0.010). The presence of dia- betes or CAN was independently associated with the half gastric emptying time after adjusting for age, gender, plasma glucose and blood pressure. Conclusions : We found a much prolonged gastric emptying time in Chinese patients with type 2 diabetes as compared to non-dia- betic controls. There was a high rate of CAN in diabetic patients, and it was associated with gastric emptying. (Acta gastroenterol. belg., 2011, 74, 28-33). |
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